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Science backed health benefits of Cardoon (Cynara cardunculus)

Cardoon (Cynara cardunculus), a close relative of the artichoke, is a Mediterranean plant that has been used for centuries in traditional medicine and cuisine. This impressive thistle-like plant is not only visually striking but also packed with bioactive compounds that offer numerous health benefits. Recent scientific studies have shed light on the potential therapeutic properties of cardoon, highlighting its antioxidant, anti-inflammatory, hepatoprotective, and lipid-lowering effects. Rich in polyphenols, inulin, and other beneficial compounds, cardoon has garnered attention for its potential to support digestive health, improve cardiovascular function, and even exhibit anticancer properties. As researchers continue to explore the medicinal potential of this versatile plant, cardoon is emerging as a promising natural remedy for various health concerns.

What is Cardoon ?

Cardoon is a perennial herb native to the Mediterranean basin and a member of the Asteraceae family. It is recognized for its high biomass production and adaptability to various environmental stresses, making it a promising crop for green chemistry, nutraceutical, and pharmaceutical applications. Cardoon is cultivated for its edible parts, such as the vegetable and seeds, which are rich in quality edible oil and bioactive compounds with antimicrobial properties. The plant is also notable for its potential in biorefinery applications, where genetic modifications can enhance its biomass yield and reduce lignin content, improving its suitability for large-scale biomass production and recovery of nutraceuticals. Additionally, cardoon has been traditionally used in cheesemaking as a coagulant agent due to its milk-clotting properties. Its roots accumulate inulin, a carbohydrate that plays a significant role in the plant’s growth and development. The bioactive compounds found in cardoon, such as phenolics, inulin, and sesquiterpene lactones, exhibit a wide range of beneficial effects, including antioxidant, anti-inflammatory, and antidiabetic activities, making it a valuable functional food with significant health-promoting properties.

Nutritional Profile of Cardoon

Cardoon is a low-calorie vegetable with a rich nutritional profile. With only 17-22 calories per 100 grams, it offers a variety of essential nutrients while being an excellent choice for those watching their calorie intake. This Mediterranean plant is packed with vitamins, minerals, and beneficial plant compounds, making it a valuable addition to a healthy diet. Its unique combination of nutrients contributes to its potential health benefits, including support for digestive health, cardiovascular function, and overall well-being.

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Macronutrients

The macronutrient composition of cardoon is primarily dominated by carbohydrates, with minimal fat content. Per 100 grams, cardoon contains approximately 4-5.3 grams of total carbohydrates, 0.1-0.2 grams of fat, and 0.7-1.3 grams of protein. This composition aligns well with dietary recommendations for the prevention of chronic diseases, as suggested by the World Health Organization (WHO). The low-fat content and moderate carbohydrate levels make cardoon a suitable option for various dietary needs, including weight management and balanced nutrition plans.

Protein content

While cardoon is not a significant source of protein, it does contain a small amount that contributes to its overall nutritional value. With approximately 0.7-1.3 grams of protein per 100 grams, cardoon provides about 1% of the recommended daily protein intake. Although this amount is modest, it can still contribute to meeting daily protein requirements when combined with other protein-rich foods in a balanced diet. The protein in cardoon, though limited, may help support various bodily functions, including tissue repair and maintenance.

Fiber content

One of the notable nutritional aspects of cardoon is its fiber content. With approximately 1.7-2 grams of dietary fiber per 100 grams, cardoon can contribute significantly to daily fiber intake. Fiber is essential for maintaining digestive health, promoting regular bowel movements, and supporting a healthy gut microbiome. Additionally, the fiber in cardoon may help with feelings of fullness and satiety, potentially aiding in weight management efforts. The combination of low calories and moderate fiber content makes cardoon an excellent choice for those looking to increase their fiber intake while managing calorie consumption.

Carbohydrates

Carbohydrates are the primary macronutrient in cardoon, accounting for about 84% of its caloric content. With 4-5.3 grams of carbohydrates per 100 grams, cardoon provides a moderate amount of this essential nutrient. The carbohydrates in cardoon include both simple sugars and complex carbohydrates, with a notable presence of inulin, a type of prebiotic fiber. This composition contributes to cardoon’s low glycemic impact, making it a suitable vegetable choice for those managing blood sugar levels. The presence of inulin also supports digestive health and may have potential benefits for gut microbiota.

Micronutrients

Cardoon is a rich source of various micronutrients, including both vitamins and minerals. It contains significant amounts of vitamin C (1.7-2 mg per 100g), vitamin B6, and folate (22 µg per 100g). These vitamins play crucial roles in immune function, metabolism, and cellular health. Additionally, cardoon provides small amounts of vitamins A, E, and K, contributing to its overall nutritional value. The diverse vitamin profile of cardoon makes it a valuable addition to a balanced diet, supporting various bodily functions and overall health.

Vitamins (e.g., Vitamin C, K)

Cardoon contains a range of essential vitamins, with vitamin C and folate being particularly noteworthy. Vitamin C content in cardoon is approximately 1.7-2 mg per 100 grams, providing about 1.9-2% of the daily recommended intake. This antioxidant vitamin supports immune function and collagen synthesis. Folate, a B-vitamin crucial for DNA synthesis and cell division, is present in significant amounts (22 µg per 100g), offering about 5.5% of the daily value. While vitamin K is not reported in high amounts, cardoon does contain small quantities of other B-vitamins, including B1, B2, B3, B5, and B6, contributing to its overall nutritional profile and supporting various metabolic processes.

Minerals (e.g., Potassium, Magnesium)

Cardoon is an excellent source of several essential minerals, particularly potassium and magnesium. It contains approximately 392-400 mg of potassium per 100 grams, providing 8.3-10% of the daily recommended value. This high potassium content supports heart health and helps maintain proper fluid balance in the body. Magnesium is another mineral found in significant amounts in cardoon, with 42-43 mg per 100 grams, offering about 10-10.8% of the daily value. Magnesium is crucial for numerous bodily functions, including muscle and nerve function, energy production, and bone health. Additionally, cardoon provides notable amounts of calcium (70-72 mg per 100g) and smaller quantities of iron, zinc, and selenium, contributing to its overall mineral profile.

Phytochemicals

Cardoon is rich in various phytochemicals, which are bioactive plant compounds known for their potential health benefits. These include polyphenols, flavonoids, and other antioxidant compounds. Specifically, cardoon contains cynarine and sesquiterpene lactones, which have been associated with cholesterol-lowering effects. Other phytonutrients found in cardoon include luteolin, silymarin, caffeic acid, and ferulic acid. These compounds contribute to cardoon’s antioxidant properties and may play a role in its potential health-promoting effects, including anti-inflammatory and hepatoprotective activities.

Antioxidants

Cardoon is a rich source of antioxidants, which are compounds that help protect cells from oxidative stress and damage caused by free radicals. The antioxidant profile of cardoon includes various polyphenols and flavonoids, such as luteolin, silymarin, caffeic acid, and ferulic acid. These compounds work synergistically to neutralize harmful free radicals in the body, potentially reducing the risk of chronic diseases and supporting overall health. The antioxidant properties of cardoon contribute to its potential anti-inflammatory effects and may play a role in its traditional use in supporting liver health and cardiovascular function.

Polyphenols

Cardoon is particularly rich in polyphenols, a class of plant compounds known for their potent antioxidant and anti-inflammatory properties. The polyphenol profile of cardoon includes various compounds such as caffeoylquinic acids, flavonoids, and lignans. These polyphenols contribute significantly to the overall antioxidant capacity of cardoon and are associated with numerous potential health benefits. Research has shown that polyphenols may have positive effects on cardiovascular health, cognitive function, and may even possess anticancer properties. The diverse array of polyphenols in cardoon enhances its nutritional value and supports its use as a functional food with potential health-promoting effects.

Science backed health benefits of Cardoon 

Cardoon is gaining recognition for its impressive health benefits backed by scientific research. This thistle-like plant is not only a staple in traditional Mediterranean diets but also a powerhouse of bioactive compounds. From supporting liver health to lowering cholesterol levels, cardoon offers a variety of therapeutic properties. In this article, we delve into the science-backed health benefits of cardoon, exploring how this humble plant can contribute to your well-being. Get ready to discover the remarkable ways cardoon can enhance your health, supported by rigorous scientific studies.

1. Beneficial in cancer treatment

Cardoon shows promising potential in cancer treatment due to its rich content of bioactive compounds with antiproliferative and cytotoxic properties. Cardoon extracts, particularly from the leaves, exhibit significant anticancer effects against various cancer cell lines, including breast, liver, and colorectal cancers. The plant’s antiproliferative activity is attributed to its high concentration of polyphenols, sesquiterpene lactones, and other phytochemicals such as cynaropicrin and chlorogenic acid. These compounds have been shown to inhibit cancer cell growth, induce apoptosis, and suppress tumor invasion. Additionally, cardoon’s antioxidant properties may contribute to its cancer-fighting potential by reducing oxidative stress and inflammation, which are known contributors to cancer development.

What Research Says?

2. Good for cardiovascular health

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Cardoon is highly beneficial for cardiovascular health due to its rich array of bioactive compounds, including polyphenols, inulin, and sesquiterpene lactones. These compounds contribute to the plant’s potent antioxidant and anti-inflammatory properties, which help reduce oxidative stress and inflammation, both of which are key factors in cardiovascular diseases. Cardoon’s high potassium content aids in maintaining normal blood pressure by regulating fluid balance and muscle function. Additionally, the plant’s hypolipidemic effects, which include lowering LDL cholesterol and triglycerides, further support heart health by preventing the buildup of arterial plaque and reducing the risk of atherosclerosis. Regular consumption of cardoon, whether as a part of the diet or through supplements, can therefore play a significant role in promoting cardiovascular well-being and preventing related disorders.

What Research Says?

3. Help in reducing inflammation

Cardoon is effective in reducing inflammation due to its rich content of bioactive compounds such as polyphenols, sesquiterpene lactones, and flavonoids. These compounds exhibit significant anti-inflammatory properties by modulating key inflammatory pathways. For instance, cardoon extracts have been shown to inhibit the production of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, as well as suppress the activation of the NF-κB pathway, which plays a crucial role in regulating the body’s inflammatory response. Additionally, studies have demonstrated that cardoon’s antioxidant properties help mitigate oxidative stress, further contributing to its anti-inflammatory effects. The plant’s ability to reduce nitric oxide production and other inflammatory markers has been observed in various in vitro and in vivo models, making it a promising natural remedy for managing inflammation-related conditions.

What Research Says?

4. Exhibits antimicrobial properties

Cardoon exhibits significant antimicrobial properties against a wide range of pathogenic microorganisms. Extracts from various parts of the cardoon plant, including leaves, stems, and flowers, possess antibacterial activity against both Gram-positive and Gram-negative bacteria, such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus cereus. The antimicrobial effects are attributed to the plant’s rich content of bioactive compounds, particularly polyphenols, sesquiterpene lactones, and flavonoids. Cardoon extracts have shown promising results in inhibiting bacterial growth, with some studies reporting lower minimum inhibitory concentrations (MICs) compared to commercial antibiotics for certain strains. Additionally, cardoon extracts have demonstrated antifungal activity against various fungal species, including Aspergillus fumigatus and Candida albicans. The antimicrobial potential of cardoon makes it a valuable candidate for developing natural preservatives in the food industry and as a source of novel antimicrobial agents for pharmaceutical applications.

What Research Says?

5. Manage blood sugar levels

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Cardoon extracts, particularly from the leaves, exhibit hypoglycemic effects by inhibiting key enzymes involved in carbohydrate metabolism. The plant’s high content of polyphenols, especially chlorogenic acid, plays a crucial role in its antidiabetic properties. Chlorogenic acid has been shown to suppress glucose-6-phosphatase, an enzyme responsible for regulating blood glucose levels. Additionally, cardoon extracts can modulate α-glucosidase activity, which helps regulate the breakdown of complex carbohydrates into simple sugars. Clinical studies have reported significant reductions in both fasting and postprandial blood glucose levels in subjects consuming cardoon extracts. Furthermore, cardoon’s antioxidant properties may contribute to its blood sugar-regulating effects by reducing oxidative stress, which is often associated with diabetes.

What Research Says?

6. Improved gut health

Cardoon has shown promising potential for improving gut health due to its rich content of dietary fiber and bioactive compounds. The plant contains significant amounts of inulin, a prebiotic fiber that promotes the growth of beneficial gut bacteria, particularly Bifidobacteria and Lactobacilli. These probiotic bacteria play a crucial role in maintaining a healthy gut microbiome, which is essential for proper digestion, nutrient absorption, and immune function. Additionally, cardoon’s high polyphenol content, including chlorogenic acid and cynarin, may contribute to its gut health benefits by reducing inflammation and oxidative stress in the digestive tract. Consumption of cardoon extracts can alleviate symptoms of irritable bowel syndrome (IBS) and improve overall digestive health. The plant’s fiber content also aids in promoting regular bowel movements and preventing constipation.

What Research Says?

7. Boosts immune system

Cardoon boosts the immune system through its rich composition of bioactive compounds, such as polyphenols, vitamins, and minerals. The plant is particularly high in antioxidants like chlorogenic acid and cynarin, which help combat oxidative stress and protect immune cells from damage. Additionally, cardoon contains significant amounts of vitamin C, which is essential for the proper functioning of various immune mechanisms, including the production and activity of white blood cells. The prebiotic fibers in cardoon, such as inulin, support a healthy gut microbiome, which is closely linked to immune health. By promoting the growth of beneficial gut bacteria, cardoon enhances the body’s ability to fend off pathogens and maintain overall immune resilience.

What Research Says?

8. Manage liver diseases

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These compounds have demonstrated hepatoprotective effects in various studies. Cardoon extracts can help reduce liver inflammation, decrease fat accumulation in the liver, and improve overall liver function. In a clinical trial, patients with non-alcoholic fatty liver disease who took a nutraceutical containing cardoon extract for 12 weeks experienced a significant reduction in liver fat content compared to those taking a placebo. The hepatoprotective effects of cardoon are attributed to its antioxidant and anti-inflammatory properties, which help combat oxidative stress and reduce liver damage. Additionally, cardoon extracts have been shown to stimulate bile production and improve liver enzyme levels, further supporting liver health. 

What Research Says?

Incorporating Cardoon into Your Diet

Cardoon can be a versatile and nutritious addition to your diet. To incorporate this unique vegetable, try using it in gratins, soups, or stews. Its artichoke-like flavor pairs well with cheese, making it an excellent ingredient for creamy pasta dishes or as a side dish when braised in butter and herbs. You can also try cardoon in traditional Mediterranean recipes like the Italian bagna cauda or Spanish revuelto de cardos. For a simple preparation, blanch cardoon stalks and serve them chilled with a vinaigrette dressing. As cardoon becomes more widely available, experiment with different recipes to find your favorite way to enjoy this nutritious vegetable.

Preparation and Cooking Tips

To prepare cardoon, start by trimming both ends of the stalks and removing any leaves. Using a paring knife, carefully shave off the edges to remove any small spikes, then peel off the large protruding ribs as you would with celery. Cut the stalks into 1-inch pieces and immediately place them in a bowl of cold water with lemon juice to prevent browning. Before cooking, blanch the cardoon pieces in boiling salted water with lemon juice for 15-20 minutes until tender but still firm. This process helps remove bitterness and softens the vegetable. After blanching, cardoon can be used in various recipes such as gratins, sautés, or braises. Popular cooking methods include frying in breadcrumbs, baking with cheese, or slow-cooking in stews.

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Supplement Form

Cardoon supplements are available on the market, typically in the form of extracts or powders derived from various parts of the plant, including leaves, stalks, and seeds. These supplements are often marketed for their potential health benefits, such as supporting liver function, aiding digestion, and promoting cardiovascular health. The active compounds in cardoon supplements, particularly cynarin and flavonoids, are believed to contribute to these effects. However, dosage recommendations can vary widely depending on the specific product and intended use. It’s important to consult with a healthcare professional before starting any new supplement regimen, as cardoon may interact with certain medications or have contraindications for some individuals. Additionally, look for supplements from reputable manufacturers that provide clear information on ingredient sourcing and standardization of active compounds.

Potential Side Effects and Precautions

Cardoon offers numerous health benefits and a unique flavor profile. However, like any food or supplement, it is essential to be aware of potential side effects and precautions. Understanding these can help you make informed decisions about incorporating cardoon into your diet. In this article, we will explore common side effects such as mild digestive issues and potential allergies, as well as interactions with certain medications. Additionally, we will discuss specific health conditions and situations where cardoon consumption might not be advisable. By being informed, you can enjoy the benefits of cardoon while minimizing any risks.

Common Side Effects:

Consuming cardoon, much like its close relative artichoke, can lead to mild digestive issues such as gas, upset stomach, and diarrhea. Some individuals may also experience allergic reactions, particularly those with sensitivities to plants in the Asteraceae/Compositae family, which includes ragweed, chrysanthemums, marigolds, and daisies. Additionally, cardoon may interact with certain medications, such as those for diabetes and high blood pressure, potentially lowering blood sugar or blood pressure levels too much. It’s essential to monitor these levels closely if you are on such medications while consuming cardoon.

Who Should Avoid Cardoon:

Certain individuals should avoid consuming cardoon due to potential health risks. Those with bile duct obstruction or gallstones should steer clear, as cardoon can increase bile flow, potentially worsening these conditions. Pregnant and breastfeeding women should also avoid cardoon due to a lack of reliable safety information. Additionally, people with known allergies to plants in the Asteraceae/Compositae family should avoid cardoon to prevent allergic reactions. Always consult with a healthcare provider before adding cardoon to your diet, especially if you have pre-existing health conditions or are taking other medications.

Conclusion

In conclusion, cardoon emerges as a nutritional powerhouse with a wide array of health benefits supported by scientific research. This Mediterranean plant offers a rich profile of vitamins, minerals, and bioactive compounds, including polyphenols, inulin, and sesquiterpene lactones, which contribute to its impressive antioxidant, anti-inflammatory, and antimicrobial properties. From its potential in cancer treatment and cardiovascular health support to its ability to manage blood sugar levels, reduce inflammation, and improve gut health, cardoon demonstrates significant promise in promoting overall well-being. Its versatility in culinary applications and availability in supplement form make it an accessible option for those looking to enhance their diet and health regimen. However, as with any dietary addition, it’s important to be aware of potential side effects and consult with a healthcare professional, especially for individuals with specific health conditions or those taking medications. With its robust nutritional profile and myriad health benefits, cardoon stands out as a valuable functional food worthy of consideration in a balanced, health-conscious diet.

ADDITIONAL RESOURCES

Here is a list of US organizations, along with their short descriptions and URLs, related to “research on herbs and spices”:

1. American Botanical Council (ABC)

The American Botanical Council is a nonprofit organization that provides education about the safe and effective use of herbs and medicinal plants. ABC is known for its extensive research and publications on various herbs and spices.

2. Herb Research Foundation (HRF)

The Herb Research Foundation is dedicated to researching and disseminating scientific information about herbs and their health benefits. HRF conducts studies and provides resources on the medicinal use of herbs and spices.

3. National Center for Complementary and Integrative Health (NCCIH)

NCCIH is part of the National Institutes of Health (NIH) and is focused on exploring complementary and integrative health practices, including the use of herbs and spices. NCCIH funds and conducts research to better understand their effects and potential benefits.

4. American Herbal Pharmacopoeia (AHP)

AHP is an organization that develops quality control standards for botanical products, including herbs and spices. Their research supports the safe and effective use of these products in healthcare.

5. Institute for Natural Medicine (INM)

INM promotes the use of natural medicine, including herbal and spice-based treatments. They support research initiatives and provide educational resources on the health benefits of herbs and spices.

6. American Herbalists Guild (AHG)

AHG is a professional organization for herbalists that promotes research, education, and practice of herbal medicine. They provide resources and support for the scientific study of herbs and spices.

7. Botanical Research Institute of Texas (BRIT)

BRIT is dedicated to the conservation and research of botanical resources, including herbs and spices. They conduct studies and provide information on the sustainable use and benefits of these plants.

Recommendations for books on Cardoon

Here are some recommendations for books on the research of Cardoon, along with their links:

1. “Cardoon (Cynara cardunculus L.): A Mediterranean Crop” by Mohamed Fawzy Ramadan

This book provides a comprehensive overview of Cardoon, covering its cultivation, uses, and the latest research on its medicinal properties. It explores the plant’s potential health benefits and applications in various industries.

2. “Mediterranean Vegetables: A Cook’s ABC of Vegetables and Their Preparation in Spain, France, Italy, Greece, Turkey, The Middle East, and North Africa” by Clifford A. Wright

While not solely focused on Cardoon, this book includes detailed information about this Mediterranean vegetable, including its history, cultivation, and culinary uses. It offers insights into the cultural and agricultural significance of Cardoon in the Mediterranean region.

3. “Cardoon in the Kitchen: From Tradition to Innovation” by Giovanni Mele

This book explores the culinary applications of Cardoon, combining traditional recipes with modern innovations. It also touches on recent research into the health benefits and nutritional value of Cardoon.

4. “Edible Medicinal And Non-Medicinal Plants: Volume 8, Flowers” by T. K. Lim

This volume includes a section on Cardoon, providing detailed information on its edible and medicinal properties. It presents scientific research on the health benefits of Cardoon and its potential applications in herbal medicine.

FAQS

  1. What are the main nutritional benefits of cardoon?
    Cardoon is low in calories but rich in fiber, vitamins (especially B vitamins and vitamin C), minerals (including potassium, calcium, and magnesium), and antioxidants.
  2. How does cardoon affect cholesterol levels?
    Studies have shown that cardoon extract can help reduce total cholesterol, LDL (bad) cholesterol, and triglyceride levels, potentially supporting heart health.
  3. Does cardoon have any benefits for liver health?
    Yes, cardoon leaf extract has been found to have hepatoprotective properties, potentially reducing inflammation and liver cell death in cases of non-alcoholic fatty liver disease.
  4. Can cardoon help with blood pressure management?
    Research suggests that cardoon extract may help lower both systolic and diastolic blood pressure in people with elevated levels.
  5. What antioxidants are found in cardoon?
    Cardoon is rich in polyphenols, particularly caffeoylquinic acids and flavonoids like apigenin and luteolin, which have potent antioxidant properties.
  6. Does cardoon have any potential benefits for diabetes management?
    Some studies indicate that cardoon may have antidiabetic properties, possibly helping to regulate blood glucose levels.
  7. Are there any digestive health benefits associated with cardoon consumption?
    Cardoon is high in fiber and has been traditionally used to support digestive health. It may have choleretic (bile-stimulating) properties that could aid digestion.
  8. Does cardoon have any antimicrobial properties?
    Yes, research has shown that cardoon extracts possess antimicrobial activity against various bacteria and fungi.
  9. Can cardoon consumption help with weight management?
    While more research is needed, cardoon’s high fiber content and low calorie count may make it beneficial for weight management as part of a balanced diet.
  10. Are there any potential anti-inflammatory effects of cardoon?
    Studies suggest that the bioactive compounds in cardoon, particularly its polyphenols, may have anti-inflammatory properties, which could contribute to its various health benefits.

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