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Science backed health benefits of Artichoke (Cynara cardunculus)

Artichokes, scientifically known as Cynara cardunculus, are more than just a culinary delight; they are a powerhouse of health benefits backed by science. Native to the Mediterranean region, these thistle-like plants have been used for centuries not only as a food source but also for their medicinal properties. Modern research has unveiled a plethora of health benefits associated with artichokes, ranging from improved digestion and liver health to reduced cholesterol levels and enhanced cardiovascular health. Rich in fiber, antioxidants, and essential nutrients, artichokes are a versatile addition to any diet, offering both flavor and functional health benefits. This article delves into the science-backed health benefits of artichokes, shedding light on why this ancient plant continues to be a modern marvel in the world of nutrition and health.

What is Artichoke ?

Artichoke is a perennial plant native to the Mediterranean region and widely cultivated for its edible flower heads, which are a staple in various Mediterranean dishes. This plant is not only valued for its culinary uses but also for its rich content of bioactive compounds, including phenolic acids, flavonoids, and inulin, which contribute to its numerous health benefits. Artichoke extracts have demonstrated significant antioxidant properties, making them effective in scavenging reactive oxygen and nitrogen species, which suggests their potential as natural antioxidants. Additionally, artichoke has been traditionally used for its hepatoprotective, anticarcinogenic, and hypocholesterolemic effects, attributed to compounds like cynarin and luteolin. The plant also plays a role in sustainable agriculture, with its by-products being utilized to extract valuable compounds like inulin, thus promoting a circular economy within the artichoke supply chain. Overall, artichoke is a multifunctional plant with significant nutritional, medicinal, and industrial applications.

Nutritional Profile

Artichokes boast an impressive nutritional profile, making them a valuable addition to any diet. Each cup of cooked artichoke (approximately 170 grams) contains about 90 calories, 20 grams of carbohydrates, 10 grams of fiber, 5 grams of protein, and only 0.6 grams of fat. They are particularly rich in essential vitamins and minerals, including folate, vitamin C, magnesium, and potassium. Additionally, artichokes are packed with antioxidants, which help combat oxidative stress and support overall health.

Overview of Vitamins and Minerals in Artichokes

Artichokes are a nutrient-dense food, providing a wide array of vitamins and minerals essential for maintaining good health. They are particularly high in folate, vitamin C, and vitamin K, along with significant amounts of magnesium, phosphorus, and potassium. These nutrients contribute to various bodily functions, including immune support, bone health, and cardiovascular health. The rich antioxidant content in artichokes also helps protect the body from free radical damage, reducing the risk of chronic diseases.

Vitamin C

Vitamin C is a vital nutrient found in artichokes, with one cup of cooked artichoke providing about 12% of the daily value (DV). This powerful antioxidant plays a crucial role in immune function, skin health, and the synthesis of collagen, which is essential for wound healing and maintaining the integrity of connective tissues. Additionally, vitamin C helps enhance the absorption of iron from plant-based foods, making it an important nutrient for vegetarians and vegans.

Vitamin K

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Artichokes are an excellent source of vitamin K, providing approximately 21% of the daily value per cup. Vitamin K is essential for blood clotting and bone metabolism. It helps in the synthesis of proteins required for blood coagulation and supports bone health by promoting the activity of osteocalcin, a protein involved in bone mineralization. Adequate intake of vitamin K can help reduce the risk of osteoporosis and fractures.

Folate

Folate, also known as vitamin B9, is abundant in artichokes, with one cup offering about 34% of the daily value. Folate is crucial for DNA synthesis and repair, making it especially important during periods of rapid growth, such as pregnancy and infancy. Adequate folate intake is essential for preventing neural tube defects in newborns and supporting overall cellular function. It also plays a role in reducing homocysteine levels, which can help lower the risk of cardiovascular diseases.

Magnesium

Magnesium is another essential mineral found in artichokes, with one cup providing about 15% of the daily value. This mineral is involved in over 300 enzymatic reactions in the body, including energy production, protein synthesis, and muscle and nerve function. Magnesium also plays a role in maintaining normal blood pressure, supporting bone health, and regulating blood glucose levels. Adequate magnesium intake is important for overall health and well-being.

Dietary Fiber

Artichokes are an excellent source of dietary fiber, with one cup containing about 10 grams, which is 40% of the daily value. Dietary fiber is crucial for maintaining healthy digestion, preventing constipation, and promoting regular bowel movements. It also helps in managing blood sugar levels, reducing cholesterol levels, and supporting weight management by promoting a feeling of fullness. High-fiber diets are associated with a lower risk of developing chronic diseases such as heart disease, diabetes, and certain types of cancer.

Caloric Content and Macronutrients

Artichokes are low in calories, with one cup of cooked artichoke containing just 90 calories. They provide a balanced macronutrient profile, including 20 grams of carbohydrates, 10 grams of dietary fiber, 5 grams of protein, and only 0.6 grams of fat. This makes artichokes an excellent choice for those looking to maintain or lose weight while ensuring they receive essential nutrients. The high fiber and protein content contribute to satiety, helping to control appetite and reduce overall calorie intake

Science backed health benefits of Artichoke

Discover the power-packed potential of artichokes! These spiky, green wonders, scientifically known as Cynara cardunculus, are more than just a delicious addition to your plate. Packed with fiber, antioxidants, and essential nutrients, artichokes have been used for centuries in traditional medicine. Now, modern science is catching up, revealing a treasure trove of health benefits that make this Mediterranean marvel a true superfood. From boosting digestive health to supporting your liver and heart, artichokes are proving to be nature’s multitasking miracle. Ready to uncover the science-backed reasons why you should be adding more artichokes to your diet? Let’s dive into the impressive list of health benefits that these tasty thistles bring to the table!

1. Manage inflammation-related disorders

Artichoke has shown promising potential in managing inflammation-related disorders, thanks to its rich content of bioactive compounds, particularly polyphenols like chlorogenic acid, cynarin, and luteolin. These compounds exhibit potent anti-inflammatory and antioxidant properties that can help mitigate various inflammatory conditions. Artichoke extract can suppress pro-inflammatory cytokines and enzymes, such as TNF-α, IL-1β, and COX-2, while also activating anti-inflammatory pathways. Artichoke extract has been found to alleviate intestinal inflammation by modulating inflammatory markers and improving gut barrier function. Additionally, the antioxidant properties of artichoke compounds help neutralize free radicals and reduce oxidative stress, which is often a key factor in chronic inflammatory conditions.

What Research Says?

2. Beneficial for liver complaints

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The plant’s rich content of bioactive compounds, particularly polyphenols like chlorogenic acid, cynarin, and flavonoids, contribute to its hepatoprotective properties. Artichoke extract can help improve liver function in patients with non-alcoholic fatty liver disease (NAFLD) by reducing liver enzymes such as ALT and AST, as well as improving ultrasound parameters. The antioxidant and anti-inflammatory effects of artichoke extract play a crucial role in protecting liver cells from oxidative stress and damage. Additionally, artichoke has been found to stimulate bile production and flow, which aids in the removal of toxins and supports overall liver function.

What Research Says?

3. Have Antioxidant Properties

Artichoke is renowned for its potent antioxidant properties, which play a crucial role in combating oxidative stress and promoting overall health. The high levels of polyphenols, such as chlorogenic acid, cynarin, and luteolin, contribute significantly to its antioxidant capacity. These compounds help neutralize free radicals, thereby reducing cellular damage and lowering the risk of chronic diseases like cancer, cardiovascular diseases, and neurodegenerative disorders. Artichokes rank among the top vegetables in terms of antioxidant content, with a high Oxygen Radical Absorbance Capacity (ORAC) score, indicating their ability to scavenge harmful free radicals effectively. Additionally, the antioxidants in artichokes support liver health by enhancing detoxification processes and protecting liver cells from damage. This makes artichokes a valuable addition to a diet aimed at improving antioxidant intake and overall health.

What Research Says?

4. Good for cardiovascular health

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Artichoke extract can help reduce total cholesterol, LDL (bad) cholesterol, and triglyceride levels, which are key risk factors for heart disease. The polyphenols found in artichokes, particularly chlorogenic acid and cynarin, contribute to these lipid-lowering effects. Additionally, artichoke extract has been found to have antihypertensive properties, helping to lower both systolic and diastolic blood pressure in individuals with elevated levels. This effect may be due to the artichoke’s ability to promote the production of nitric oxide, which helps dilate blood vessels and improve blood flow. Furthermore, the high antioxidant content of artichokes, including flavonoids and anthocyanins, helps protect against oxidative stress and inflammation, both of which play roles in the development of cardiovascular diseases. The fiber content in artichokes also contributes to heart health by helping to manage cholesterol levels and supporting overall digestive health. 

What Research Says?

5. Inhibit the growth of cancer cells

The polyphenolic compounds found in artichoke extracts, particularly chlorogenic acid, cynarin, and flavonoids like luteolin and apigenin, have been associated with antiproliferative and pro-apoptotic effects on cancer cells. Artichoke extracts can reduce cell viability, inhibit cell growth, and trigger apoptotic mechanisms in different cancer cell lines, including breast, colorectal, and oral squamous carcinoma. Artichoke polyphenols could induce apoptosis and decrease the invasive potential of these cells. Additionally, artichoke extracts have been found to suppress cancer cell growth by inducing premature senescence and modulating DNA hypomethylation and lysine acetylation levels in total proteins. The anticancer effects of artichoke extracts are often attributed to their ability to increase reactive oxygen species (ROS) production in cancer cells, upregulate pro-apoptotic genes like Bax and caspase-9, and downregulate anti-apoptotic genes like Bcl-2.

What Research Says?

6. Treat digestive and bowel problems

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These compounds have been found to stimulate bile production and flow, which aids in digestion and helps alleviate symptoms of indigestion such as bloating, nausea, and abdominal discomfort. Efficacy of artichoke leaf extract in reducing symptoms of irritable bowel syndrome (IBS) and functional dyspepsia. People taking artichoke leaf extract for six weeks experienced a significant reduction in IBS symptoms, with 96% of participants rating the extract as equally effective or better than other IBS treatments. Another study found that artichoke leaf extract reduced IBS symptoms by 26% and improved quality of life by 20% after two months of treatment. The prebiotic fiber inulin, found in artichokes, also contributes to digestive health by promoting the growth of beneficial gut bacteria and improving bowel regularity.

What Research Says?

7. Manage blood sugar levels

Artichoke has demonstrated significant potential in managing blood sugar levels, making it a valuable natural remedy for individuals with diabetes or impaired glucose tolerance. The bioactive compounds in artichokes, particularly chlorogenic acid and cynarin, play a crucial role in enhancing insulin sensitivity and reducing blood glucose levels. Artichoke extract can significantly lower fasting blood sugar levels and improve glycemic control in overweight individuals with impaired fasting glycemia (IFG). Additionally, artichoke extract has been found to promote glucose uptake and consumption, decrease glucose production, and increase glycogen storage in liver cells, thereby improving overall glucose metabolism. The antioxidant properties of artichokes also help mitigate oxidative stress, which is often associated with insulin resistance and diabetes.

What Research Says?

8. Aids in Weight Management

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This Mediterranean plant is low in calories but high in fiber, making it an excellent addition to weight loss diets. The high fiber content, particularly inulin, helps promote feelings of fullness and reduces hunger, which can lead to decreased calorie intake. Additionally, artichokes have a diuretic effect that can help eliminate excess fluid retention in the body. Artichoke extract may inhibit digestive enzymes like pancreatic lipase and α-amylase, potentially reducing fat absorption. The plant’s antioxidant compounds, including cynarin and flavonoids, may also support metabolic health and fat digestion. 

What Research Says?

9. Support Immune System

This Mediterranean plant is packed with antioxidants, particularly polyphenols, which help combat oxidative stress and reduce inflammation in the body. These antioxidants, including vitamin C, can repair damaged cells that may impair immune function. Artichokes are also a good source of inulin, a prebiotic fiber that promotes the growth of beneficial gut bacteria, which plays a crucial role in maintaining a healthy immune system. Additionally, artichokes contain minerals like magnesium and potassium, which are essential for proper immune function. Artichoke extract can improve the immune response and antioxidant system. 

What Research Says?

10. Good for Skin Health

Artichoke is highly beneficial for skin health due to its rich content of antioxidants, vitamins, and polyphenols. The antioxidants, including ferulic acid, caffeic acid, and silymarin, help combat free radicals, thereby reducing oxidative stress and preventing premature aging. Artichoke extract is also rich in vitamin C, which boosts collagen production, enhancing skin elasticity and reducing the appearance of wrinkles and fine lines. Additionally, the anti-inflammatory properties of artichoke extract help soothe irritated skin, making it effective for conditions like acne, eczema, and rosacea. Clinical studies have shown that artichoke extract can improve skin firmness and elasticity, contributing to a more youthful and radiant complexion. Regular use of artichoke-based skincare products can lead to minimized pores, improved skin texture, and a healthier overall appearance.

What Research Says?

How to incorporate artichoke into a balanced diet

To incorporate artichoke into a balanced diet, consider the following tips:

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As a nutrient-dense side dish:

Steam or roast whole artichokes and serve them as a low-calorie, high-fiber side dish alongside lean proteins and whole grains. This preparation method allows you to enjoy the full nutritional benefits of the entire artichoke, including the leaves and heart.

In salads:

Add marinated artichoke hearts to salads for extra flavor, texture, and nutrients. This is an easy way to boost your vegetable intake and add variety to your meals.

As part of main dishes:

Incorporate artichoke hearts into pasta dishes, casseroles, or use them as a pizza topping. They pair well with Mediterranean flavors like lemon, garlic, and olive oil, making them versatile for various recipes.

As a healthy snack:

Enjoy steamed artichoke leaves as a low-calorie snack. Pair them with a healthy dip like hummus or a yogurt-based sauce for added protein and flavor.

In dips and spreads:

Blend artichoke hearts with ingredients like Greek yogurt, spinach, or white beans to create nutritious dips for vegetables or whole-grain crackers. This is a great way to enjoy artichokes while also increasing your intake of other healthy foods.

As part of breakfast dishes:

Add chopped artichoke hearts to omelets, frittatas, or breakfast sandwiches for a nutrient boost in the morning. This can help increase your vegetable intake early in the day.

As a meat substitute:

Use the meaty texture of artichoke hearts as a substitute in vegetarian or vegan dishes. This can help reduce overall meat consumption while still providing a satisfying meal.

In combination with other vegetables:

Pair artichokes with other nutrient-rich vegetables like bell peppers, tomatoes, or leafy greens to create balanced, colorful dishes. This approach ensures you’re getting a wide variety of nutrients in your meals.

Side effects of consuming artichokes

Based on the research, here are the key side effects of consuming artichokes:

Digestive Issues

Artichokes can cause gastrointestinal discomfort in some people. This may include gas, bloating, upset stomach, and diarrhea. These side effects are generally mild and often subside as the body adjusts to increased artichoke consumption.

Allergic Reactions

Some individuals may experience allergic reactions to artichokes, especially those who are sensitive to plants in the Asteraceae/Compositae family. This family includes ragweed, chrysanthemums, marigolds, and daisies. Allergic symptoms can range from mild (such as itching or rash) to severe (such as difficulty breathing or anaphylaxis).

Bile Duct and Gallbladder Concerns

Artichokes may increase bile flow, which could potentially worsen conditions like bile duct obstruction or gallstones. Individuals with these conditions should consult a healthcare provider before consuming artichokes or artichoke extract.

Medication Interactions

Artichoke extract may interact with certain medications, particularly those metabolized by the liver. It’s important to consult with a healthcare provider if you’re taking any medications, especially those related to cholesterol or liver function.

Taste Alterations

Some people report experiencing a metallic or “off” taste after consuming artichoke extract. This is generally temporary and resolves on its own.

Conclusion

In conclusion, artichokes offer a wealth of science-backed health benefits that make them a valuable addition to any diet. From managing inflammation and supporting liver health to improving cardiovascular function and aiding in weight management, artichokes demonstrate impressive versatility in promoting overall wellness. Their rich antioxidant content, particularly polyphenols like chlorogenic acid and cynarin, contributes to their potent anti-inflammatory and protective effects. Artichokes also show promise in regulating blood sugar levels, inhibiting cancer cell growth, and supporting digestive and skin health. With their impressive nutritional profile, including high fiber content and essential vitamins and minerals, artichokes not only taste great but also provide numerous health-boosting properties. As with any dietary change, it’s important to consider potential side effects and interactions, especially for individuals with specific health conditions or those taking certain medications. Incorporating artichokes into a balanced diet can be a delicious and nutritious way to support your health and well-being.

ADDITIONAL RESOURCES

Here are some US organizations related to research on vegetables, along with their short descriptions and URLs:

1. The American Society for Horticultural Science (ASHS)

ASHS is dedicated to advancing the knowledge and application of horticultural science, including vegetable research. They support research, education, and outreach activities in horticulture.

2. University of California Agriculture and Natural Resources (UC ANR)

UC ANR conducts research and extension programs on a wide range of agricultural topics, including vegetable production, pest management, and sustainable farming practices.

Recommendations for books on artichokes

Here are some recommendations for books on “research on Artichoke” with links:

1. “Artichoke Production and Marketing” by W.D. Langhans

This book covers various aspects of artichoke production, including research on cultivation practices, pest management, and marketing strategies.

2. “The Globe Artichoke Genome” by Bruno Mezzetti, George Scorza, Bruno Mezzetti, Jean-Michel Audergon

This book provides an in-depth look at the genetics and genomics of the globe artichoke, offering valuable insights into the molecular biology and breeding of this important crop.

3. “Antioxidants in Vegetables and Nuts – Properties and Health Benefits” edited by Chukwuebuka Egbuna, Jaya Soneji

This book includes a section on artichokes, discussing their antioxidant properties and health benefits, supported by scientific research.

4. “Vegetable Production and Practices” by Gregory E. Welbaum

This comprehensive book covers the production practices for various vegetables, including artichokes, with a focus on research-based methods for improving yield and quality.

5. “Biotechnology of Neglected and Underutilized Crops” edited by S.M. Jain, S.D. Gupta

This book explores the biotechnological advancements in the cultivation of neglected and underutilized crops, including artichokes, highlighting recent research and innovations.

6. “Artichokes: Health Benefits and Nutritional Information” by Patrick Kimuyu

This book delves into the health benefits and nutritional profile of artichokes, supported by scientific research on their medicinal properties.

FAQS

  1. What are the main health benefits of consuming artichokes?
    Artichokes offer numerous health benefits, including improved digestion, lower cholesterol levels, better liver function, reduced blood pressure, and potential anticancer properties. They are also rich in antioxidants and fiber, which contribute to overall health and well-being.
  2. How do artichokes help with digestive issues?
    Artichokes contain high levels of fiber and compounds like cynarin that promote digestive health. Studies have shown that artichoke extract can reduce symptoms of irritable bowel syndrome (IBS) and improve overall gut health by up to 26.4% after two months of treatment.
  3. Can artichokes help lower cholesterol levels?
    Yes, research indicates that artichoke extract can help reduce cholesterol levels. Studies have shown that it can lower total cholesterol, LDL (bad) cholesterol, and triglycerides in people with high cholesterol.
  4. What role do artichokes play in liver health?
    Artichokes contain compounds like silymarin that can protect the liver from damage. Studies have shown that artichoke extract can improve symptoms of nonalcoholic fatty liver disease and may even reduce mortality rates in cases of cirrhosis.
  5. How do artichokes affect blood pressure?
    Artichokes are rich in potassium, which helps regulate blood pressure. A 2021 systematic review found that taking artichoke supplements for 12 weeks significantly lowered high blood pressure.
  6. What antioxidants are found in artichokes?
    Artichokes are rich in polyphenols, particularly cynarin and chlorogenic acid. These antioxidants help fight inflammation and may contribute to the vegetable’s potential anticancer properties.
  7. Can artichokes help with weight management?
    Artichokes are low in calories and high in fiber, which can help promote feelings of fullness. The inulin in artichokes also acts as a prebiotic, potentially aiding in weight management by supporting gut health.
  8. Are there any potential side effects of consuming artichokes?
    While generally safe, artichokes can cause side effects such as gas, upset stomach, and diarrhea in some people. Those with allergies to plants in the Asteraceae family should be cautious.
  9. How might artichokes benefit heart health?
    Artichokes may support heart health through their cholesterol-lowering effects, blood pressure regulation, and anti-inflammatory properties. They also provide a good source of plant-based protein, which is associated with lower risk of heart disease.
  10. Is there any evidence for artichokes’ anticancer properties?
    While research is still in early stages, some studies suggest that the polyphenols in artichokes may have anticancer properties. A 2020 study found that artichoke extract slowed cell growth and killed squamous cell cancer lines in laboratory conditions, but human trials are still needed to confirm these effects.

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