An uncommon cancer affecting bone marrow cells in which abnormal cells that resemble both lymphocytes (white blood cells) and plasma cells produce an abnormal protein, an immunoglobulin known as IgM. The protein causes weakness, fatigue, drowsiness, pale skin, a tendency to bleed easily, fever, weight loss, dizziness, headaches, and enlarged lymph nodes. People with a large concentration of IgM can develop hyperviscosity, a thickening of the blood, which can result in sluggish blood flow and may cause stroke or congestive heart failure.
A disease of plasma cells in which there is macroglobulinemia marked by excess production of immunoglobulin M (IgM). Peak incidence is in the sixth and seventh decades. The disease is more common in men. Findings include anemia due to infiltration of the bone marrow with lymphocytes and plasma cells, weight loss, neurological disturbances, blurred vision, bleeding disorders, cold sensitivity, generalized lymphadenopathy, and hyperviscosity of the blood.
A form of lymphoma where lymphocytes, a kind of white blood cell, overproduce a protein known as immunoglobulin M (IgM), which is typically made to combat diseases. This condition is most prevalent in men over the age of 50.
The overproduction of IgM thickens the blood, restricting its smooth flow through tiny blood vessels. Common symptoms include tiredness, headaches, dizziness, vision problems, easy bruising and bleeding, as well as numbness in the hands and feet. Enlargement of the spleen, liver, and lymph nodes may also occur.
While there isn’t a cure, treatments can alleviate symptoms. Plasmapheresis, a process where a machine extracts excessive IgM from the blood plasma, can reduce blood thickness. Additionally, anticancer medications and corticosteroids might be administered.