Group of wide‐spectrum antibiotics seldom used in treatment of oral infections but may be used for rhinogenic infections. Some are natural (i.e., isolated from certain species of Streptomyces) and others are produced semi‐synthetically. Tetracyclines and their analogs inhibit protein synthesis by their action on microbial ribosomes and have antimatrix metalloproteinase (MMP) activity. All have similar toxic and pharmacologic properties, differing mainly in their absorption and suitability for various modes of administration. They are effective against a broad range of aerobic and anaerobic gram‐positive and gram‐negative bacteria, as well as Rickettseae, Chlamydiae, and Mycoplasmas. Because of the binding to calcium, it is not advisable to use tetracyclines in the treatment of infections in children.
An antibiotic originally produced by Streptomyces viridifaciens, but used mostly in synthetic form. It is an inhibitor of aminoacyl-tRNA binding during protein synthesis.
An antibiotic of a group used to treat a wide range of bacterial diseases such as chlamydia. However, they are deposited in bones and teeth and cause a permanent yellow stain in teeth if given to children.
A range of broad-spectrum antibiotics derived from cultures of Streptomyces, especially Str. rimosus and Str. aureofaciens, usually orally administered. In addition to the broad bacteriological spectrum, some antiviral activity has been noted. The action is mainly bacteriostatic. The various forms of tetracycline include oxytetracycline, lymecycline, demethylchlortetracycline, doxycycline and tetracycline itself (these are the BP approved names). On oral dosage, blood levels of 2 – 4 μg/ml are obtained, and toxicity is minimal.
Any of a family of antibiotics derived from Streptomyces bacteria, including chlortetracycline, oxy- tetracycline, and doxycycline. They are known under many trade names, and are used to treat a variety of bacterial and rickettsial infections. Tetracyclines are not used during pregnancy or in young children because they cause discoloration of children’s teeth. Other adverse effects include gastrointestinal disturbances, suprainfections, and allergic reactions.
A class of antibiotics used to treat bacterial infections. Tetracyclines are used for many diseases, including Rocky Mountain spotted fever typhus fever, and tick fevers; upper respiratory infections; pneumonia; pelvic infection, gonorrhea, and urinary tract infections. Tetracyclines are also used to treat severe acne; trachoma, a chronic eye infection; and conjunctivitis (“pink eye”). Tetracyclines are often prescribed for people who are allergic to penicillin. A woman who is pregnant should not take tetracycline. There are several different types of tetracyclines, including doxycycline, minocycline, oxytetracycline, and tetracycline.
One of a group of antibiotic compounds derived from cultures of Streptomyces bacteria. These drugs, which include chlortetracycline, doxycycline, oxytetracycline, and tetracycline, are effective against a wide range of bacterial infections. They are usually given by mouth to treat various conditions, including respiratory-tract infections, syphilis, and acne. Side-effects such as nausea, vomiting, and diarrhea are fairly common. In addition, suppression of normal intestinal bacteria may make the patient susceptible to infection with tetracycline-resistant organisms. Tetracyclines should not be administered after the fourth month of pregnancy and their use should be avoided in young children.
A group of broad- spectrum antibiotics which include oxytetracycline, tetracycline, doxycycline, lymecycline, minocycline, and demeclocycline.
A bacteriostatic antibiotic used, for example, to treat acne, chlamydia, and atypical pneumonia.