Unsafe quantities of pathogenic microorganisms or their products in blood or tissues.
A condition in which the body is fighting a severe infection that has spread via the bloodstream.
The presence of bacteria in the bloodstream.
Also known as systemic inflammatory response syndrome, this life-threatening condition (“septic shock”) occurs when the body’s immune system over-responds to infection (e.g., by gram-negative bacteria) in which release of bacterial endotoxin (lipopolysaccharide, or LPS) occurs. Those immune system cells (e.g., macrophages, etc.) overproduce numerous inflammatory agents (e.g., cytokines), which induce fever, shock, and sometimes organ failure.
The presence of various forms of pus-forming or other pathological organisms, or their toxins, in the blood or tissue.
the presence of bacteria and their toxins in the body, which kill tissue and produce pus, usually following the infection of a wound.
Infection due to identifiable microorganisms or their products in the blood or tissues.
Destruction of tissue by bacterial toxins; contamination; infection.
An inflammatory response to infection characterized by fever, increased heart and respiratory rates, and decreased blood pressure.
Poisoning of body cells by infectious organisms or by the toxic substances they produce.
A system-wide response to bacterial infection of a wound or tissues, which may lead to the rapid multiplication of bacteria and an accumulation of bacterial toxins in the bloodstream.
The putrefactive destruction of tissues by disease-causing bacteria or their toxins.
Poisoning by the products of the growth of micro-organisms in the body and by material released from body cells in response. The general symptoms which accompany it are those of inflammation. Sepsis is prevented by the various procedures mentioned under asepsis, and is treated locally with antiseptics and systemically with antibiotics.
A systemic inflammatory response to infection, in which there is fever or hypothermia, tachycardia, tachypnea, and evidence of inadequate blood flow to internal organs. The syndrome is a common cause of death in critically ill patients. Roughly 50% of patients with sepsis die; between 200,000 and 400,000 deaths due to sepsis occur annually in the U.S. Pathogenic organisms, including bacteria, mycobacteria, fungi, protozoa, and viruses, may initiate the cascade of inflammatory reactions that constitute sepsis. The number of patients with sepsis has increased significantly in the last 25 years as a result of several factors including the aging of the population; the increased number of patients living with immune suppressing illnesses (e.g., organ transplants); the increased number of patients living with multiple diseases; and the increased use of invasive or indwelling devices in health care, which serve as portals of entry for infection.
Blood poisoning refers to a condition known as systemic or body-wide infection.
Bacterial infection of a wound or bodily tissue that results in the creation of pus or the proliferation of bacteria within the bloodstream.
The typical physical response, often accompanied by a fever, that arises from the influence of toxic substances produced by harmful bacteria, typically in the context of pathogenic infections.