Group of cephalosporin antibiotics possessing some ability to kill gram-positive cocci such as staphylococci and streptococci, as well as aerobic gram-negative rods. Some agents, namely cefotetan, cefoxitin, and cefmetazole, can be used to treat anaerobic infections. Examples of second-generation cephalosporins are cefamandole, cefuroxime, cefonicid, ceforanide, cefixime, cefaclor, cefoxitin, cefotetan, and cefmetazole.