Retrolental fibroplasia (RLF)

Scar tissue behind the lens of the eye, preventing light rays from reaching the retina. Caused by the administration of excessive oxygen to premature infants. May result in blindness.


A condition in which fibrous tissue develops behind the lens of the eye, resulting in blindness.


A condition in which a mass of scar tissue forms in back of the lens of the eye.


A condition in which the posterior portion of the eye’s lens develops a fibrous membrane causing near blindness or actual blindness. This condition most often occurs in premature babies who are exposed to large amounts of oxygen while in an incubator during their early days or weeks of life.


A medical condition, also referred to as retinopathy of prematurity, primarily impacting the vision of premature newborns. The typical trigger for retrolental fibroplasia is the administration of elevated levels of oxygen to premature infants as a component of the therapy for respiratory distress syndrome, a condition marked by acute lung issues leading to breathing challenges.


An overabundance of oxygen prompts the tissues along the periphery of the retina (the inner layer sensitive to light at the rear of the eye) to cease the functioning of their blood vessels. When oxygen levels normalize once again, the impacted tissues might generate extensions of fresh blood vessels and fibrous scars into the vitreous humor (the gel-like substance filling the back segment of the eye). This process could potentially disrupt vision and lead to detachment of the retina.


Laser treatment has the potential to effectively address retrolental fibroplasia.


Inflammation and the formation of scars in tissues located at the rear of the abdominal cavity characterize retroperitoneal fibrosis. This condition frequently obstructs the ureters, impeding the passage of urine from the kidneys to the bladder. In more severe instances, this can lead to kidney failure.


Retroperitoneal fibrosis commonly manifests in middle-aged men and its origins remain uncertain; it could potentially stem from an autoimmune dysfunction. Nonetheless, the condition might be linked to extended use of the medication methysergide (utilized in migraine treatment). Managing this condition may encompass the use of corticosteroid medications, the placement of a stent (a rigid tube) to alleviate ureteral blockage, and surgical intervention.


 


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