A condition in a woman where, by age 18 or older, she has never menstruated secondary amenorrhea.
Delay of menarche until after age 16 or the absence of secondary sex characteristics after age 14. Typical causes include congenital abnormalities of reproductive structures, such as the mullerian ducts; absence of the uterus and/or vagina; imperforate hymen; or ovarian failure secondary to chromosomal abnormalities, such as occurs in Turner’s syndrome.