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A mutation in the gene for aldolase that results in an accumulation of fructose 1,6-bisphosphate. Aldolase catalyzes the cleavage of fructose 1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate.  

Damage to the liver due to excessive ethanol (alcohol) consumption.  

Abstinence of alcohol by an alcoholic individual is associated with neurologic symptoms, cardiovascular symptoms, and fluid volume deficit.  

The metabolism of alcohol drives up the need for thiamin, niacin, pantothenic acid, and pyridoxine.  

Due to a decreased immune response, alcoholics are at high risk for developing the end result of a process initiated by sepsis known as septic shock.  

Niacin is part of the coenzyme NADH and NADPH. Both are needed for the metabolism of alcohol. Excess alcohol consumption drives up the need for this vitamin.  

Metabolic pH falls when excessive alcohol intake occurs.  

Alcoholism is characterized by low blood levels of phosphate. This impairs blood pH regulation.  

Alcoholism may be characterized by low blood levels of sodium.  

Alcoholism appears to increase the need for magnesium in the diet.