Nonsoluble twisted fibers found inside the brain’s cells. These tangles consist primarily of a protein called TAU, which forms part of a structure called a microtubule. The microtubule helps transport nutrients and other important substances from one part of the nerve cell to another. In Alzheimer’s disease, however, the tau protein is abnormal and the microtubule structures collapse.
Misshaped filaments on the surface of the brain associated with Alzheimer’s-type dementia.
Buildups of entangled protein fragments within brain nerve cells that serve as a diagnostic characteristic of Alzheimer’s disease.