A small protein that induces the differentiation and survival of particular target neurons (nerve cells).
A protein produced by the salivary glands (and also in tumors) that greatly increases growth/reproduction of nerve cells and guides the formation of neural networks. In the brain, NGF is thought to increase the production of the messenger chemical, acetylchoHne, by protecting and stimulating those neurons that produce acetylcholine. Because those (acetylcholine-producing) neurons are typically the first to be destroyed in an Alzheimer’s disease victim, NGF holds potential to be used to counteract (some of) the effects of the disease. NGF is also necessary for normal development of the hypothalamus, a brain structure that regulates a number of hormones. Human T cells appear to have receptors for NGF, which could explain the “mindbody connection” between a person’s emotional well-being and physical health (i.e., NGF may be a go-between for the brain and the immune system). NGF was discovered by Rita Levi-Montalcini in 1954.
A chemical substance that stimulates the growth of developing nerves as they establish connections with various parts of the body.
Also known as NGF, a substance that influences differentiation, growth, and maintenance of nerve cells. Studies are under way to try to synthesize nerve growth factor for use in treating many neurological conditions, including ALS (amyotrophic lateral sclerosis).
A protein necessary for the growth and maintenance of sympathetic and certain sensory neurons.
A protein akin to insulin that influences the growth and upkeep of nerve cells.