An enzyme found in the central nervous system (CNS) and peripheral organs, including the brain, gastrointestinal tract, and liver, that breaks down biogenic amines (neurotransmitters) and other monoamines (e.g., tyramine), rendering them inactive. Inhibition of this enzyme (for which there are two forms, mao-a and mao-b) by certain antidepressant drugs (monoamine oxidase inhibitors [maois]) may alleviate depressed states by increasing the levels of biogenic amines in the brain.
Enzyme that oxidises amines; inhibitors have been used clinically as antidepressant drugs, and consumption of amine-rich foods such as cheese may cause a hypertensive crisis in people taking the inhibitors.
An enzyme that breaks down biogenic amines (neurotransmitters), rendering them inactive. Found in many body organs, including the brain. Inhibition of this enzyme by certain antidepressant drugs (MAOI’s) may result in alleviation of depressed states.
The enzyme that catalyses the removal of amine groups (e.g. dopamine, noradrenaline).
A drug having a central nervous system. stimulant effect and that blocks a specific enzyme, increasing a neurotransmitter that helps to elevate and relieve depression.
An enzyme which breaks down the catecholamines to their inactive forms.
A copper-containing enzyme that catalyzes the removal of oxygen from epinephrine, tyramine, and serotonin, inactivating them and reducing neuronal activity. Inhibitors of MAO are valuable drugs for treating depression.
An enzyme that breaks down monoamine neurotransmitters such as dopamine, norepinephrine, and serotonin.
Enzyme, found in most tissues, especially the liver and nervous system, that catalyzes the oxidation of many body compounds, including epinephrine, norepinephrine, and serotonin.
An enzyme; it is inhibited by a group of drugs that are effective in the treatment of depression.