An anemia that results from inhibition of DNA synthesis in red blood cell production, often due to a deficiency of vitamin B12 or folate and is characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow.
Anemia characterized by an abundance of large immature nucleated red blood cells. A typical feature of folacin deficiency.
Blood disorder in which large, immature and dysfunctional red blood cells circulate; associated with pernicious anemia and folic acid deficiency.
A blood disorder characterized by larger than normal red blood cells. Abnormal precursors of red blood cells called megaloblasts (from Greek roots meaning “big cell buds”) occur in the bone marrow and give this anemia its name. Megaloblastic anemia commonly results from deficiency in vitamin B12 or folic acid (also known as folate). It can also be caused by leukemia, multiple myeloma, certain hereditary disorders, and some chemotherapy agents. The most common type of megaloblastic anemia is pernicious anemia.
Anemia in which megaloblasts are found in the blood.
A form of anemia distinguished by unusually enlarged red blood cells, often attributable to insufficiencies in folate or vitamin B12.