Hyposplenism is a medical term used to describe a state where the spleen’s functionality is reduced. If the spleen is not working properly, it leads to a decrease in the production of antibodies, lymphocytes, and phagocytes, which are vital in combating harmful invaders such as microorganisms. Consequently, those with Hyposplenism are more prone to certain serious infections. It is generally recommended for individuals whose spleen has either been surgically removed or is not operating effectively, to receive a pneumococcal vaccination and engage in long-term antibiotic therapy.