A disorder caused by a build-up of a waste product, uric acid, in the bloodstream. Excess uric acid settles in joints causing inflammation, pain and swelling.
Inflammation of joints caused by uric acid crystals lodging in them.
Painful disease caused by accumulation of crystals of uric acid in the synovial fluid of joints; may be due to excessive synthesis and metabolism of purines, which are metabolised to uric acid, or to impaired excretion of uric acid.
A metabolic disease that is a form of acute arthritis, marked by inflammation of the joints and great pain.
A disease that causes episodes of acute arthritis and inflammatory swelling in one or more joints. Gout usually starts in a well-used, oft traumatized joint like the right big toe or knee, and usually starts in the night, during the time that Traditional Chinese Medicine calls “liver hour,” 2:00 to 4:00 AM. (allowing for daylight saving time). The inflammation is caused by uric acid crystals that have lodged in the joint’s white blood cells and is started by hyperuricemia. Most folks with gout have a hereditary tendency to poorly excrete uric acid in urine as they get older, and it stays in the blood until . . . gout.
A condition or uric acid metabolism. It occurs in paroxysms and is characterized by painful inflammation of parts of the joints and an excessive amount of uric acid in the blood.
Increased uric acid level in blood and sporadic episodes of acute arthritis.
A metabolic disease resulting in deposit of urates in the joints.
A disease in which unusual quantities of uric acid are produced and form crystals in the cartilage round joints.
A condition in which uric acid excretion is impaired. The excess uric acid in the blood is deposited in tissues and joints, causing inflammation and discomfort.
Disease in which a defect in uric acid metabolism causes the acid and its salts to accumulate in the blood and joints, causing pain and swelling of the Joints (especially the big toe area), accompanied by fever and chills. The disease is more common among men than women and usually has a genetic basis. If untreated, the disease causes destructive tissue changes in the joints and kidneys. Treatment includes a purine-free diet and use of drugs to reduce inflammation and to increase the excretion of uric acid salts or decrease their formation. Also called gouty arthritis.
Disorder that occurs most often in men due to excessive levels of uric acid in the blood; acute attacks cause sudden, severe pain in the great toe or hands as uric acid moves from the blood into the soft tissues and forms masses of crystals with soft-tissue swellings known as tophi.
A form of arthritis that most often occurs in men and is caused by excessive amounts of uric acid in the blood. The excess uric acid may be deposited in joint cartilage and other tissues, where it can cause inflammation, swelling, and severe pain.
A form of arthritis that produces sudden and severe attacks of pain, swelling, and tenderness in joints. Gout most commonly affects the large joint of the big toe but also occurs in the knees, ankles, hands, and wrists. The attacks, which often resolve within 5 to 10 days, are usually interspersed with periods when there are no symptoms. The discomfort of gout is associated with excess amounts of uric acid in the blood, a condition called hyperuricemia.
A disease in which a defect in uric acid metabolism causes an excess of the acid and its salts (urates) to accumulate in the bloodstream and the joints. It results in attacks of acute gouty arthritis and chronic destruction of the joints and deposits of urates {tophi) in the skin and cartilage, especially of the ears. The excess of urates also damages the kidneys, in which stones may form. Treatment with drugs that increase the excretion of urates (uricosuric drugs) or with allopurinol, which slows their formation, has largely controlled the disease.
A term used to describe several disorders associated with a raised concentration of uric acid in the blood, of which various forms of inflammatory arthritis and kidney disease are the most important. The condition has an overall prevalence in the UK of around 0-6 per cent.
A form of arthritis marked by the deposition of monosodium urate crystals in joints and other tissues. Any joint may be affected, but gout usually begins in the knee or the first metatarsophalangeal joint of the foot.
A metabolic disease characterized by painful inflammation of certain joints caused by deposits of salts of uric acid (urates) in them.
A condition characterized by the accumulation of uric acid, a byproduct typically excreted through urine, within the joints and kidneys.
Gout is a prevalent metabolic disorder characterized by recurrent arthritis attacks, typically affecting a single joint, often the base of the big toe. The condition arises from elevated levels of uric acid in the blood, and the arthritis occurs as a result of the accumulation of uric acid crystals in the joint tissues.
The joint affected by gout becomes red, swollen, and highly sensitive to touch. These painful attacks can last for a few days and tend to recur. In some cases, fever may accompany the attacks. As gout persists and reoccurs, it may involve more joints, leading to continuous pain caused by chronic inflammation and joint damage. Furthermore, gout can be associated with the formation of kidney stones or, in rare instances, kidney damage due to the deposition of crystals in the kidney tissue.
The diagnosis is verified through tests on blood or fluid extracted from the affected joint to determine the levels of uric acid.
The pain and inflammation of acute (of sudden onset) attacks can be controlled by nonsteroidal anti-inflammatory drugs (NSAIDs) or by colchicine. If these drugs are ineffective, a corticosteroid drug may be injected into the joint. Many people require no further treatment. Long-term treatment with drugs that help to lower urate levels, such as allopurinol or sulfinpyrazone, can stop or reduce the frequency of recurrent attacks. These drugs, however, may trigger an attack at the start of treatment, so are initially prescribed with NSAIDs.
A genetic condition primarily affecting men that results in the accumulation of biurate substances in and around joints, causing intense inflammation. The big toe joint is most often impacted. Acute episodes can be alleviated with medications like butazolidin or colchicum. Preventative treatment involves dietary adjustments and medications like probenecid, which modify the levels of uric acid in the blood and boost its elimination through urine.