A hormone that stimulates the pituitary gland to secrete three hormones: gonadotrophic hormone, luteinising hormone and follicle-stimulating hormone. Gonadorelin can be made artificially and given by intravenous injection. It is used to stimulate the ovaries when treating infertile women, and to investigate suspected disease of the hypothalamus. Analogues of the hormone (buserelin and goselerin) are chemically similar and can be used to suppress release of gonadorelin, so cutting the production of pituitary hormones. The two analogues are given to treat endometriosis, breast cancer and prostate cancer.
A pharmaceutical form of gonadotropin-releasing hormone (GnRH), which is naturally produced by the hypothalamus. GnRH acts as a stimulant for the nearby pituitary gland, prompting the secretion of two gonadotropin hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Gonadorelin can be administered via injection and is utilized for investigating suspected hypothalamic diseases.
Gonadorelin analogues are synthetic versions of gonadorelin that closely resemble the natural hormone. These analogues induce the hypothalamus to release less GnRH, resulting in decreased levels of FSH and LH. They are employed to counter the effects of natural hormones during gonadorelin treatment for infertility. Moreover, these drugs are used in the treatment of conditions such as endometriosis and hormone-dependent cancers, including breast cancer and prostate cancer.