The use of restriction endoglycosidases to (enzymatically) remove sugar (i.e., oligosaccharide) “branches” from glycoprotein (i.e., part protein, part oligosaccharide) molecules. One reason to perform such glycoprotein remodeling would be to remove one or more oligosaccharide branches so that the glycoprotein is less or no longer antigenic (i.e., triggers an immune response). This allows the glycoprotein to be injected into the body (e.g., for pharmaceutical purposes) without incurring an unwanted immune response.