Glanzmann’s thrombasthenia

A rare autosomal recessive abnormality of platelet glycoprotein Ilb-IIIa, characterized by easy bruising and epistaxis that sometimes requires blood transfusions. Bleeding is prolonged, clot retraction is diminished, and platelets do not aggregate during blood coagulation or after addition of adenosine diphosphate. Treatments include platelet transfusions, progestational agents, and iron replacement, among others.


 


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