Study of, or discovery of, what traits/functions are conferred to an organism by given (gene) sequences. Typically, functional genomic study follows after discovery of gene sequences found via structural genomics study. Some methods utilized to determine which traits/functions result from
which gene(s) are:
- Site-directed mutagenesis (SDM), to compare two same-species organisms possessing two different genes at the same site on the genome
- Antisense DNA sequence, to compare two same-species organisms (one ofwhich has gene at same site ”turned off via antisense DNA)
- Reporter gene, to compare two same-species organisms (with two different genes at same site on genome) via a “reporter” gene adjacent to gene/site, to detect presence of desired trait/function