A structural abnormality of the heart and great blood vessels that occurs during intrauterine development. Abnormalities are commonly classified by the presence or absence of cyanosis. Acyanotic abnormalities include atrial and ventricular septal defects, coarctation of the aorta, and patent ductus arteriosus. Cyanotic defects include tetralogy of Fallot, transposition of the great vessels, and hypoplastic left-sided heart syndrome.