In children, an abnormal pupillary flash or reflection from the eye that may be momentary; may be white, yellow, or pink; and is best seen under diminished natural illumination. This reflex, which may be noticed first by a parent, may be caused by various conditions, the most important of which is retinoblastoma. It is also observed in tuberous sclerosis, inflammatory eye diseases, and certain congenital malformations of the eye.