Category: L

A protein that prevents formation of blood clots. This occurs because LACI inhibits the controlled series of zymogen activations (enzymatic cascade) which causes the formation of fibrinogen (precursor to fibrin), leading subsequently to clot formation.  

A “fat loving” molecule or portion of a molecule. Relating to or having strong affinity for fats or other lipids. A substance soluble in oil or a nonpolar solvent. A drug or other chemical that is more soluble in fat than in water. Having an affinity for fat; absorbing or easily dissolving in fat. having…

The process of “attaching” a drug or a toxin to a monoclonal antibody, or another homing molecule of the immune system. Because this attachment must be reversible, so that the homing molecule can release the drug or toxin after delivering that drug or toxin to the desired site in the body (e.g., delivery of a…

A short synthetic duplex oligonucleotide containing the target site for some restriction enzyme. It may be added to the ends of a DNA (deoxyribonucleic acid) fragment prepared by cleavage with some other enzyme reconstructions of recombinant DNA.  

A depiction of gene loci (on chromosomes) based on the frequency of recombination (of linked genes) in the offspring’s genome.  

Includes all loci (in DNA molecule) that can be connected (directly or indirectly) by linkage relationships; equivalent to a chromosome.  

The regions (domains) of the antibody (molecule’s) “light chain” that vary in their amino acid sequence. The “chains” (of atoms) comprising the antibody (immunoglobulin) molecule consist of a region of variable (V) amino acid sequence and a region in which the amino acid sequence remains constant (C). An antibody molecule possesses two antigen binding sites,…

The formation of a phosphodiester bond to link two adjacent bases separated by a nick in one strand of a double helix of DNA (deoxyribonucleic acid). The term can also be applied to blunt-end ligation and to the joining of RNA (ribonucleic acid) strands. Process of tying off blood vessels or constricting other body tissues…

An enzyme used to catalyze the joining of single-stranded DNA segments. The general term for a class of enzymes that catalyze the joining of the ends of two chains of DNA.  

A term used to describe a substance (the ligand) that has the capacity for specific and noncovalent (reversible) binding to some protein. A ligand may be a coenzyme for a specific enzyme. The ligand can be covalently attached (immobilized) by means of the appropriate chemical reaction to the surface of certain porous column material. When…