A breakdown product of heme (a part of haemoglobin in red blood cells) produced by the liver that is excreted in bile which causes a yellow discoloration of the skin and eyes when it accumulates in those organs.
Orange- to yellow-colored compound in the blood plasma, produced by the breakdown of hemoglobin following the normal or pathologic destruction of red blood cells. It is collected by the liver to produce bile.
A bile pigment resulting from the breakdown of heme, the nonprotein, iron-containing portion of hemoglobin. In excessive hemoglobin breakdown, bilirubin may spill into the blood and produces a deep yellow color in the skin. This is called jaundice. Excess billirubin in the blood is called bilirubinemia.
Orange-yellow pigment in bile. The abnormal accumulation of bilirubin in the blood and skin causes jaundice, and testing for bilirubin levels in the blood helps in the diagnosis of several diseases.
A substance formed during the breakdown of hemoglobin in the blood; present in urine in conditions such as obstructive disease of the gallbladder or liver disease.
A breakdown product of hemoglobin, the blood pigment that transports oxygen. When red blood cells are destroyed, the bilirubin that results from the breakdown of hemoglobin is transported to the liver and excreted as part of the bile into the gallbladder and small intestine. A small amount of the bilirubin reenters the bloodstream after it is taken up by the small intestine; later it is excreted in the urine. Measuring the amount of bilirubin in the blood and urine, tests provide information about whether the liver and gallbladder are functioning normally. If an obstruction is blocking the bile ducts or gallbladder, the level of bilirubin in the blood increases. Abnormally high levels of bilirubin can cause jaundice, a yellowish discoloration of the skin and the sclera (whites of the eyes), that can be a sign of liver or gallbladder disease. In addition to liver and gallbladder disease, hemolytic anemia can cause bilirubin levels to rise.
The chief pigment in human bile. It is derived from haemoglobin, which is the red pigment of the red blood corpuscles. The site of manufacture of bilirubin is the reticuloendothelial system. When bile is passed into the intestine from the gall-bladder, part of the bilirubin is converted into stercobilin and excreted in the faeces. The remainder is reabsorbed into the bloodstream, and of this portion the bulk goes back to the liver to be re-excreted into the bile, whilst a small proportion is excreted in the urine as urobilinogen.
The orange-colored or yellowish pigment in bile. It is derived from hemoglobin of red blood cells that have completed their life span and are destroyed and ingested by the macrophage system of the liver, spleen, and red bone marrow. When produced elsewhere, it is carried to the liver by the blood. It is changed chemically in the liver and excreted in the bile via the duodenum. As it passes through the intestines, it is converted into urobilinogen by bacterial enzymes, most of it being excreted through the feces. If urobilinogen passes into the circulation, it is excreted through the urine or re-excreted in the bile. The pathological accumulation of bilirubin leads to jaundice in many cases, such as physiological jaundice of the newborn.
A crimson-hued substance found in both bile and blood, where an excessive buildup of bilirubin leads to the manifestation of jaundice.
Bilirubin, the primary pigment found in bile, originates from the breakdown of hemoglobin, the pigment present in red blood cells. Excessively elevated levels of bilirubin lead to the characteristic yellow discoloration observed in jaundice. The byproducts resulting from the breakdown of bilirubin contribute to the brown coloration of feces.