Beta-hydroxy-beta-methylbutyrate (HMB) has been available as a dietary supplement for several years. HMB is produced during the metabolism of leucine, but is not considered an essential nutrient itself. Initial research suggested that in untrained subjects who initiated a 3-week resistance training program, daily supplementation of 1.5 and 3.0 daily grams of HMB exhibited enhanced strength and lean body mass in comparison to resistance training only.62