Balo disease, also known as concentric sclerosis, is a childhood neurological disorder characterized by brain demyelination. Rapid and progressive loss of the fatty covering around nerve fibers in the brain results in various neurological symptoms depending on the brain areas affected. The damage to the brain consists of irregular patches in a series of widening concentric circles. The cause of Balo disease is unknown, and symptoms can progress rapidly over several weeks or more slowly over 2—3 years. Balo disease may be the result of a slow virus or the involvement of autoimmune factors. It may be a variant of multiple sclerosis or an unusual form of Schilder’s disease. Balo disease affects both male and female children.
A rare, rapidly progressing form of multiple sclerosis. It differs from other multiple sclerosis variants, in that it is not characterized by relapses and remissions.