Author: Glossary
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Monofilament
A strand of nylon used to assess sensation in peripheral nerves, especially in the feet of patients with diabetes mellitus and other neuropathic conditions. The inability to feel the prodding of a strand of monofilament on the foot in one or more locations is diagnostic of diabetic peripheral neuropathy.
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Monodermoma
A neoplasm originating in one germinal layer.
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Monodal
Connected with one terminal of a resonator so that the patient acts as a capacitor for entrance and exit of high-frequency currents.
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Monocytopenia
Diminished number of monocytes in the blood.
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Monocrotic
Indicating a single pulse wave with no notches in it.
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Monocontaminated
Infected with a single species of organism.
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Monoclonal B-cell lymphocytosis
The presence of excessive numbers of B lymphocytes in the bloodstream, all derived from a single parent cell. This condition sometimes precedes chronic lymphocytic leukemia, although it is often found in patients who never develop the disease.
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Monoclonal antibody therapy
The use of monoclonal antibodies to suppress immune function, kill target cells, or treat specific inflammatory diseases. Because of their high level of specificity, they bind to precise cellular or molecular targets. A potential problem associated with the use of monoclonal antibodies is an allergic reaction to the foreign antigens in the antibody, since they…
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Toxin-linked monoclonal antibody
A monoclonal antibody to which a cell-killing drug has been attached. The antibody combines preferentially with receptors on undesired cells (e.g., cancer cells) and delivers its lethal drug to those cells but not to healthy cells and tissues. To increase their effectiveness and decrease immune responses to these cells, genes for antigen binding sites from…
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Radionuclide-linked monoclonal antibody
A monoclonal antibody to which a radioisotope has been attached. The antibody attaches to receptors on the surface of undesired cells (e.g., cancer cells) and delivers a dose of radiation directly to those cells, leaving healthy cells and tissues relatively unaffected.