The actual number of neutrophils in a cubic millimeter of blood. The approximate normal range is 3000 to 6000 cells/mm3. This figure is measured before and after drugs are given that may lower neutrophil counts, such as those used in cancer chemotherapy. Generally, chemotherapy is not given unless the patient’s ANC is greater than 1000. Patients with an ANC of less than 500 cells/mm3 are at high risk for infection.