Loss of vitality, degeneration of cells and tissues, those involved in hereditary degenerative disorders.
Degeneration or loss of function without apparent cause; for example, retinal abiotrophy is progressive degeneration of the retina leading to impaired vision, occurring in genetic disorders such as ‘retinitis pigmentosa.
Premature loss of vitality or degeneration of tissues and cells with consequent loss of endurance and resistance.