An exopeptidase, a circulating enzyme that participates in the body’s renin-angiotensin system (RAS) which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction.
Enzyme, in the blood vessels of the lungs, which activates angiotensin. Many of the drugs for treatment of hypertension are ACE inhibitors.
Important target for the treatment of cardiac insufficiency.
An enzyme found on the surface of blood vessels in the lungs and other tissues with vasopressive action.
The enzyme responsible for converting angiotensin I to angiotensin II in the kidney.
A class of blood pressure reducing drugs. ACEs are thought to act by suppressing the renin-angiotensin-aldosterone system, but they are also effective at times in patients with low-renin hypertension.
An enzyme normally found in the capillary endothelium throughout the vascular system. It converts angiotensin I (a part of the renin-angiotensin aldosterone mechanism of the kidney) to angiotensin II, the final step in the renin-angiotensin mechanism. The latter stimulates aldosterone secretion and therefore sodium retention.
Angiotensin-converting enzyme (ACE) is a crucial substance responsible for the conversion of angiotensin I into its active counterpart, angiotensin II. Medications that hinder the activity of ACE are commonly referred to as ACE inhibitor drugs. These pharmaceutical agents find application in managing conditions such as hypertension, characterized by elevated blood pressure, as well as heart failure, which signifies a decline in the heart’s pumping efficacy.
A crucial focus for treating heart failure.