Glyphosate oxidase

An enzyme that (via catalysis) chemically breaks down glyphosate (i.e., the active ingredient in some herbicides). Glyphosate oxidase is produced in nature by acclimated microorganisms. In 1988, Michael Heitkamp discovered a strain of Pseudomonas bacteria which possessed a gene (GO) that caused those particular Pseudomonas bacteria to produce unusually large amounts of glyphosate oxidase. That GO gene can be incorporated into a variety of crop plants (e.g., soybean, cotton, etc.) in order to enable those plants to survive post-emergence applications of glyphosate-containing herbicide. Additionally, a plant can be genetically engineered to survive postemergence applications of glyphosate-containing herbicide via insertion of gene (cassette) for plant production of the enzyme CP4 EPSPS.


 


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