Vasodilators are a category of medications designed to expand blood vessels. This group includes ACE inhibitors, alpha-blockers, calcium channel blockers, and nitrates. These drugs are often prescribed for conditions where the abnormal constriction of blood vessels restricts blood flow, thereby limiting oxygen supply to tissues. Such conditions include angina pectoris and peripheral vascular disease. Vasodilators are also employed in the treatment of high blood pressure and heart failure, conditions characterized by reduced heart pumping efficiency. Side effects of these medications can include facial flushing, headaches, dizziness, fainting, and ankle swelling.