A pneumatic compression device for application to an edematous limb. It works best when combined with elevation of the limb and manual massage. The device, which may be single-chambered or multichambered, is designed to provide calibrated, sequential pressure to the extremity. This action “milks” edema fluid from the extremity. It is essential that the device be used in the early phase of the development of lymphedema. If the affected lymph vessels develop fibrotic changes (i.e., scar tissue), then pneumatic compression devices are of questionable benefit.