Any biochemical precursors to male hormones. In women with polycystic ovaries, elevated levels of pre-androgens such as androstenedione and dehydroepiandrosterone (DHEA) are found in the bloodstream. These steroid hormones are synthesized in the adrenal glands; DHEA, DHEA sulfate, and androstenedione are converted in target tissues (such as the prostate gland) into dihydrotestosterone, which produces masculinizing characteristics and stimulates the growth of prostate cancers. Pre-androgen levels fall as people age. Decreases in pre-androgens cause some of the symptoms of perimenopause and menopause.