Jaundice caused by the fragmentation of red blood cells and the release of unconjugated bilirubin in the bloodstream. This finding is associated with hemolytic anemia (HA). Because the bilirubin is not conjugated by the liver, it is not soluble in water and does not discolor the inane. Many conditions may be responsible, including congenital HA; sickle cell anemia; autoimmune HA (e.g., in infectious mononucleosis or Mycoplasma pneumoniae infections); microangiopathic HA (e.g., in hemolytic uremic syndrome); or transfusion-associated HA.