Nutrients which are alleged or proven to be active in preventing or treating disease. Vitamins, minerals, herbal remedies, and other supplements are the major classes of such products. Examples, with some of the claims made for them, are beta-carotene (prevention of cancer); fish oils, niacin, oat bran (prevention of heart disease); fiber-based appetite suppressants (weight control); garlic (for cholesterol reduction), and calcium supplements (prevention or treatment of osteoporosis). A large sale of these products occurs in “nutrition stores,” rather than pharmacies. For many of them, the benefits are not proven, most of them cannot be patented, and to qualify them so that they could be sold as over-the-counter (OTC) drugs would require that their promoters provide substantiated statements on their benefits and risks.