Greig cephalopolysyndactyly syndrome is characterized by craniofacial anomalies and polydactyly and syndactyly of the hands and feet. This syndrome is inherited as a fully penetrant autosomal dominant disorder. It has four major malformation components: postaxial polydactyly, preaxial polydactyly, syndactyly, and craniofacial anomalies. These four manifestations are quite variable, making the diagnosis difficult in mildly affected nonfamilial cases. In other words, they are not uniformly expressed. The origin of this syndrome may be a translocation of one or more chromosomes and may be closely linked to the region of the translocation itself. Development tends to be normal, except in the area of motor development, due to deformities of the hands and feet.